DI- AND MULTIFUNCTIONAL AMINE-MODIFIED OLIGO- AND POLYSACCHARIDE DERIVATIVES AS ANTI-INFECTIVE SUBSTANCES AND THE USE THEREOF

摘要

The invention relates to the use of an oligo- or polysaccharide (degree of polymerization (DP) values greater than 10) constructed from a basic unit, comprising hydroxyl groups carrying at least in part substituents having di-, tri- or tetramine functions without permanent charge, as antibacterial and antimycotic agents, wherein the oligo- or polysaccharide constructed from a basic unit can be obtained by derivatisation of the hydroxyl groups of an oligo- or polysaccharide to form leaving groups, obtaining a derivatised oligo- or polysaccharide, followed by a reaction of the derivatised oligo- or polysaccharide with an amine having at least two amino functions capable of nucleophilic substitution, to form an amino-substituted oligo- or polysaccharide by nucleophilic substitution, wherein the hydroxyl groups of the oligo- or polysaccharide are substituted at least in part by the amine, having at least two amino functions capable of nucleophilic substitution, with an average degree of substitution having a value > 0.1, wherein the average degree of substitution is defined as the quotient of the number of amines with at least two amino functions capable of a nucleophilic substitution that are introduced into the oligo- or polysaccharide by the substitution, divided by the number of original hydroxyl groups of the oligo- or polysaccharide, multiplied by the number of original hydroxyl groups per oligo and polymer basic unit.