发明名称 |
DEIMMUNIZED SERUM-BINDING DOMAINS AND THEIR USE FOR EXTENDING SERUM HALF-LIFE |
摘要 |
The present invention is directed to a polypeptide (for example, an antigen-binding molecule) that comprises a polypeptide portion of a deimmunized serum-binding protein capable of binding to said serum protein. The presence of the serum-binding protein extends the serum half-life of the polypeptide, relative to the serum half-life of the polypeptide if lacking the polypeptide portion of the deimmunized serum-binding protein. The invention also pertains to methods and uses that employ such molecules. |
申请公布号 |
EP2714079(A4) |
申请公布日期 |
2015.01.14 |
申请号 |
EP20120789439 |
申请日期 |
2012.05.16 |
申请人 |
MACROGENICS, INC. |
发明人 |
BONVINI, EZIO;BARAT, BHASWATI;HUANG, LING;JOHNSON, LESLIE S. |
分类号 |
A61K39/395;C07K16/28;C07K16/32;C07K16/44 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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