Process for preparation of heterocyclic thiol

摘要

A process for preparing 2-mercaptothiazole by reacting a water soluble salt of dithiocarbamic acid with 2-haloacetaldehyde characterised in that either the 2-haloacetaldehyde is added to a slum of the salt of dithiocarbamic acid in solid form in a water-miscible diluent in which the salt is substantially insoluble, or the 2-haloacetaldehyde and a solution of the the salt of dithiocarbamic acid are separately and simultaneously delivered at substantially equimolar rates of addition to a reaction vessel containing a water-miscible diluent in which the salt is substantially insoluble.