| 发明名称 |
PROCESS FOR THE PREPARATION OF VORINOSTAT |
| 摘要 |
The present invention relates to an improved process for the preparation of the active pharmaceutical ingredient vorinostat. In particular it relates to a process for preparing vorinostat substantially free from impurities. |
| 申请公布号 |
US2015018424(A1) |
申请公布日期 |
2015.01.15 |
| 申请号 |
US201414506741 |
申请日期 |
2014.10.06 |
| 申请人 |
GENERICS [UK] LIMITED |
发明人 |
Gore Vinayak G.;Patil Madhukar S.;Bhalerao Rahul A.;Mande Hemant M.;Mekde Sandeep G. |
| 分类号 |
C07C259/06;A61K31/167 |
主分类号 |
C07C259/06 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A process for the preparation of vorinostat comprising:
(a′) reacting suberic acid with hydroxylamine, or a salt thereof, to form N-hydroxy-7-carboxy-heptanamide; and (b′) reacting the N-hydroxy-7-carboxy-heptanamide formed in step (a′) with aniline, or a salt thereof. |
| 地址 |
HERTFORDSHIRE GB |
