METHODS OF TREATMENT WITH ANGIOPOIETIN-2 ANTIBODIES
摘要
The disclosure is directed to methods and uses of antibodies or antigen-binding fragments thereof against Angiopoietin-2 (Ang-2). Specifically, the disclosure is direct to the use of anti-Ang2 antibodies or antigen-binding fragments thereof for treating ischemia. The methods disclosed are useful for reducing microvascular permeability, increasing microvascular perfusion, reducing inflammation in a tissue, and treating or ameliorating diseases associated with ischemia and/or reperfusion injury. The disclosed methods are also useful for protecting solid organ transplant tissue and treating or preventing chronic tissue transplant rejection.
申请公布号
EP2822594(A1)
申请公布日期
2015.01.14
申请号
EP20130758582
申请日期
2013.03.07
申请人
MEDIMMUNE, LLC;ALITALO, KARI;SYRJALA, SIMO;LEMSTRÖM, KARI
发明人
ALITALO, KARI;SYRJALA, SIMO;LEMSTRÖM, KARI;LEOW, CHING, CHING;HERBST, RONALD;CONNOR, JANE