The invention describes epistatic interactions between single nucleotide polymorphisms on genes associated with blood pressure and provides an application for their use in a method to determine an individual's susceptibility to hypertension and hence whether anti-hypertensive treatment will be beneficial for said individual. In addition gene expression levels are also linked to blood pressure and may also be used to determine susceptibility to hypertension.
申请公布号
EP2823054(A2)
申请公布日期
2015.01.14
申请号
EP20120810305
申请日期
2012.12.21
申请人
RANDOX LABORATORIES LTD.
发明人
VISVIKIS-SIEST, SOPHIE;EL SHAMIEH, SAID;MURRAY, HELENA;LAMONT, JOHN;FITZGERALD, PETER