发明名称 |
Vaccine composition comprising autologous epidermal growth factor or a fragment or a derivative thereof having anti-tumor activity and use thereof in the therapy of malignant diseases |
摘要 |
The invention provides novel uses of EGF and vaccine compositions comprising EGF. In particular, autologous EGF, or a fragment or a derivative thereof, is used as an active immunization against the proliferation of EGF-dependent tumors, or other EGF-dependent diseases. Autologous EGF is preferably coupled to a carrier protein, such as tetanus toxoid or Cholera toxin B chain. The vaccine compositions according to the invention will usually comprise an adjuvant such as aluminum hydroxide.
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申请公布号 |
US5894018(A) |
申请公布日期 |
1999.04.13 |
申请号 |
US19960604332 |
申请日期 |
1996.02.21 |
申请人 |
CENTRO DE IMMUNOLOGIA MOLECULAR |
发明人 |
DAVILA, AUGUSTIN BIENVENIDO LAGE;MARINELLO, GISELA GONZALEZ;RAMIREZ, BELINDA SANCHEZ;PEZTANA, EDUARDO SUAREZ;DELGADO, IRENE BEAUSOLEIL;GANDOLF, GILDA NUREZ |
分类号 |
A61K39/00;A61K39/385;A61K39/395;(IPC1-7):A61K39/00;A61K39/40 |
主分类号 |
A61K39/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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