| 发明名称 |
ANTIBODY AND ANTIGEN RECOGNIZING TUMOR-INITIATING CELLS AND USE THEREOF |
| 摘要 |
Disclosed is a method for searching, identifying, or validating a marker CACNA2D1 of tumor-initiating cells. The method comprises a step of immunizing an animal using HEP-12 cells originating from a recurrent tumor and rich in originating cells. Also disclosed is a monoclonal antibody specially recognizing CACNA2D 1 or antigen-binding fragments thereof, and the use thereof for treating or preventing tumors or diseases or conditions related to CACNA2D1. |
| 申请公布号 |
EP2682475(A4) |
申请公布日期 |
2015.01.14 |
| 申请号 |
EP20120749191 |
申请日期 |
2012.02.22 |
| 申请人 |
BEIJING INSTITUTE FOR CANCER RESEARCH |
发明人 |
ZHANG, ZHIQIAN;ZHAO, WEI;WANG, LIMIN;HAN, HAIBO;XING, BAOCAI |
| 分类号 |
C12Q1/02;A61K39/00;A61K39/395;A61K45/06;A61P35/00;C07K16/18;C07K16/30;C12N5/20;C12Q1/68;G01N33/574;G01N33/577;G01N33/68 |
主分类号 |
C12Q1/02 |
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