| 摘要 |
Provided are an anti-inflammatory agent containing, as an active ingredient, at least one selected from amino acid derivatives represented by formula (I) (see formula I) wherein Ar represents an optionally substituted 2-hydroxyaryl group. n is 0 or 1, R2 represents a hydrogen atom or a side chain of an .alpha.-amino acid or a .beta.-amino acid, X represents -O- or -NH- , R1 represents a hydrogen atom or a group that forms, together with R2 and an adjacent atoms. a cyclic structure of pyroglutamic acid, and R3 represents a hydrogen atom, an alkyl group having from 1 to 22 carbon atoms or an alkenyl group having from 2 to 22 carbon atoms, and salts thereof, and toiletries or skin external products containing the same. The anti-inflammatory agent of the invention inhibits expression of an inflammatory protein and activation of a gene transcription control factor that participates therein, and exhibits a good feeling upon use acid a safety.
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