发明名称 |
FUSION PROTEIN COMPRISING DIPHTHERIA TOXIN NON-TOXIC MUTANT CRM197 OR FRAGMENT THEREOF |
摘要 |
Provided in the present invention are a diphtheria toxin non-toxic mutant CRM197 or a fragment thereof as an adjuvant in a fusion protein and the use thereof to enhance the immunogenicity of a target protein fused therewith, for example, an HEV capsid protein, or an influenza virus M2 protein or an immunogenic fragment thereof. Also provided is a method for enhancing the immunogenicity of a target protein, comprising the fusion expression of the CRM197 or the fragment thereof with the target protein to form a fusion protein. Further provided is a fusion protein comprising the CRM197 or the fragment thereof and a target protein, the CRM197 or the fragment thereof enhancing the immunogenicity of the target protein. The present invention also provides an isolated nucleic acid encoding the fusion protein, a construct and a vector comprising said nucleic acid, and a host cell comprising the nucleic acid. |
申请公布号 |
EP2716661(A4) |
申请公布日期 |
2015.01.14 |
申请号 |
EP20120793630 |
申请日期 |
2012.06.01 |
申请人 |
XIAMEN UNIVERSITY;XIAMEN INNOVAX BIOTECH CO., LTD. |
发明人 |
LI, SHAOWEI;SONG, CUILING;YANG, CHUNYAN;GU, YING;LUO, WENXIN;XIA, NINGSHAO |
分类号 |
C07K19/00;A61K38/16;A61K47/48;A61P1/16;A61P31/14;A61P31/16;C12N15/62 |
主分类号 |
C07K19/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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