Phosphoramidate derivatives of 5-fluoro-2′-deoxyuridine for use in the treatment of cancer

摘要

Phosphoramidate derivatives of 5-fluoro-2′-deoxyuridine are disclosed for use in the treatment of cancer, especially in the treatment of cancer where the patient shows resistance, for example, in a patient with cells with a lowered level of nucleoside transporter proteins and/or with nucleoside kinase-deficient cells and/or with mycoplasma-infected cells and/or with cells with a raised level of thymidylate synthase.;

主权项

1. A compound which is 5-fluoro-2′-deoxyuridine-5′-O-[1-naphthyl(benzoxy-L-alaninyl)]phosphate (CPF373), or a pharmaceutically acceptable salt or metabolite thereof.