Methods for regulation of p53 translation and function

摘要

The present invention relates to novel methods for modulating the activity of p53 tumor suppressor protein by affecting p53 translational regulation. More specifically, the invention relates to novel methods for modulating p53 mRNA translation in a cell by affecting a function of a p53 5′-untranslated region (5′UTR), including its interaction with proteins such as Ribosomal Protein L26 (RPL26), nucleolin, and p53. The invention also relates to the use of these methods for treating cancer, neurodegenerative disorders and minimizing the negative effects of cellular stresses.

主权项

1. A method for decreasing induction of the p53 tumor suppressor protein in a cell, which method comprises administering to the cell a nucleic acid-based molecule which competes with Ribosomal Protein L26 (RPL26) for interaction with a 5′-untranslated region (5′UTR) of p53 mRNA, and wherein said competition for the interaction of RPL26 with the 5 ′UTR of p53 mRNA is effective for decreasing induction of p53 tumor suppressor protein.