Medical devices having inorganic particle layers

摘要

An expandable medical device having a particle layer disposed over a reservoir containing a therapeutic agent. The particle layer has a first porosity when the medical device is in the unexpanded configuration and a second porosity when the medical device is in the expanded configuration. The particle layer comprises a plurality of micron-sized or nano-sized particles. In certain embodiments, the particles are not connected to each other, and as such, the different porosities are provided by changes in the spacing between the particles as the medical device is expanded/unexpanded. Also disclosed are medical devices having a particle layer, wherein the particle layer comprises a plurality of encapsulated particles, and methods of coating medical devices with particles.

主权项

1. An expandable medical device having an expanded configuration and an unexpanded configuration, the medical device comprising:
a reservoir containing a therapeutic agent, the reservoir being a polymer layer comprising a polymeric material and the therapeutic agent; and a particle layer disposed over the reservoir, wherein the particle layer comprises inorganic particles comprised of one or more inorganic materials, the inorganic particles being adhered to the polymer layer, and at least some of the inorganic particles being embedded in the polymer layer; wherein the particle layer has a first porosity when the medical device is in an unexpanded configuration and a second porosity when the medical device is in an expanded configuration, the first porosity being negligible or zero so as to substantially restrict release of the therapeutic agent from the reservoir, and the second porosity being relatively greater than the first porosity so as to permit a therapeutically effective release profile of the therapeutic agent.