Fluorescent carbon nanoparticles

摘要

Disclosed are photoluminescent particles. The particles include a core nano-sized particle of carbon and a passivation agent bound to the surface of the nanoparticle. The passivation agent can be, for instance, a polymeric material. The passivation agent can also be derivatized for particular applications. For example, the photoluminescent carbon nanoparticles can be derivatized to recognize and bind to a target material, for instance a biologically active material, a pollutant, or a surface receptor on a tissue or cell surface, such as in a tagging or staining protocol.

主权项

1. A method for detecting the presence of a compound in a sample comprising:
contacting a sample with a photoluminescent carbon nanoparticle, the photoluminescent carbon nanoparticle comprising a core and a passivation agent coupled to a surface of the core, the core being less than about 100 nanometers in size and being formed exclusively of one of the following: amorphous carbon, graphite, crystalline carbon, amorphous carbon with one or more metals embedded in the amorphous carbon, graphite with one or more metals embedded in the graphite, or crystalline carbon with one or more metals embedded in the crystalline carbon, the passivation agent terminating reactive bonds at the surface and rendering the reactive bonds chemically passive, wherein the core surface is photoluminescent with the passivation agent coupled to the core and the core surface is not photoluminescent absent the passivation agent; binding the photoluminescent carbon nanoparticle to the compound to form a complex, wherein the photoluminescent carbon nanoparticle comprises a specific binding member for the compound; and detecting the compound according to the photoluminescent properties of the photoluminescent carbon nanoparticle bound thereto.