| 发明名称 | High purity heparin and production method therefor | ||
| 摘要 | The present invention provides a high purity heparin useful to be a pharmaceutical product, cosmetics, research reagent, or the like, and a method for producing the same, more specifically, a heparin which does not substantially contain a nitrous acid degradation-resistant impurity and a method for producing a heparin, comprising mixing an aqueous solution of 5 to 30% by weight of the heparin with ethanol having an amount (volume) 0.2 to 1 times the amount (volume) of the aqueous heparin solution to obtain a colloidal precipitate of heparin. | ||
| 申请公布号 | US8932867(B2) | 申请公布日期 | 2015.01.13 |
| 申请号 | US201113822825 | 申请日期 | 2011.09.13 |
| 申请人 | University of Miyazaki;Fuso Pharmaceutical Industries Ltd. | 发明人 | Muguruma Michio;Murata Hiroshi |
| 分类号 | C08B37/00;A61K31/727;G01N30/14 | 主分类号 | C08B37/00 |
| 代理机构 | Browdy and Neimark, PLLC | 代理人 | Browdy and Neimark, PLLC |
| 主权项 | 1. A method for detecting or measuring a nitrous acid degradation-resistant mucopolysaccharide or a nitrous acid degradable mucopolysaccharide contained in a mucopolysaccharide, which comprises: i) degrading the mucopolysaccharide with nitrous acid at pH of 1.0 to 7.0, a reaction temperature of −10 to 40° C., a reaction time of 0.5 to 60 minutes, and an amount of 10 to 1000 mg of nitrous acid used to 1 g of the mucopolysaccharide; and ii) analyzing the degraded product of the step (i) by HPLC. | ||
| 地址 | Miyazaki JP | ||