Pyridazine compounds, compositions and methods

摘要

The invention relates to novel chemical compounds, compositions and methods of making and using the same. In particular, the invention provides pyridazine compounds and/or related heterocyclic derivatives, compositions comprising the same, and methods of making and using pyridazine compounds and/or related heterocyclic derivatives and compositions comprising the same, for modulation of cellular pathways (e.g., signal transduction pathways), for treatment or prevention of inflammatory diseases (e.g., Alzheimer's disease), for, research, drug screening, and therapeutic applications.

主权项

1. A method for reducing neuroinflammation to treat a disease or condition which presents neuroinflammation in a subject comprising administering to the subject a compound of the formula Ib:wherein:
R1 is a piperazinyl radical which is substituted with a pyrimidinyl or pyridinyl radical; R2 and R3 are independently hydrogen, hydroxyl, alkyl, alkenyl, alkynyl, alkenylene, alkoxy, alkenloxy, cycloalkyl, cycloalkenyl, aryl, aryloxy, arylalkoxy, aroyl, heteroaryl, heterocylic, acyl, acyloxy, sulfonyl, sulfinyl, sulfenyl, amino, imino, azido, thiol, thioalkyl, thioalkoxy, thioaryl, nitro, ureido, cyano, halo, silyl, silyloxy, silylalkyl, silythio, ═O, ═S, carboxyl, carbonyl, carbamoyl, or carboxamide and R4, R5 and R6 are independently hydrogen, alkyl, alkoxy, halo or nitro; or a pharmaceutically acceptable salt thereof.