Methods and compositions comprising sequential administration opioid receptor agonists

摘要

Methods and compositions for the alleviation of pain in a patient. The methods and compositions sequentially administer a therapeutically effective amount of first compound having opioid receptor agonist activity, followed by a therapeutic effective amount of a second or subsequent compound(s) having opioid receptor agonist activity, one or more non-opioid analgesic compounds or one or more hybrid opioid compounds, or mixtures thereof. The methods and compositions effectively alleviate pain with a lower incidence of opioid-induced side effects.

主权项

1. A method for alleviation of pain in a patient in need thereof, comprising sequentially administering to the patient an effective amount of a first compound with opioid receptor agonist activity followed by one or more second or subsequent compounds with opioid receptor agonist activity,
wherein the first compound with opioid receptor agonist activity and the one or more second or subsequent compounds with opioid receptor agonist activity are in a ratio of about 1:9 to about 1:1 by weight.