发明名称 |
Preservation of ergothioneine |
摘要 |
Compositions comprising ergothioneine and a trimethylamine absorber are provided. Also provided are methods for preventing, reducing or minimizing the fishy, amine odor, due to trimethylamine, that is associated with the processing and/or storage of a preparation containing ergothioneine, by combining with the ergothioneine, during processing or prior to storage, a trimethylamine absorber in an amount sufficient to prevent the detection of any trimethylamine odor by the human nose. A method is further provided for ameliorating the methylamine odor associated with an aqueous ergothioneine-containing preparation after it has developed a fishy trimethylamine odor. |
申请公布号 |
US8933245(B2) |
申请公布日期 |
2015.01.13 |
申请号 |
US201213671955 |
申请日期 |
2012.11.08 |
申请人 |
ELC Management LLC |
发明人 |
Yarosh Daniel B. |
分类号 |
A61K47/12;A61K8/00;A61K8/30 |
主分类号 |
A61K47/12 |
代理机构 |
|
代理人 |
Miller Cynthia R. |
主权项 |
1. A method for sequestering trimethylamine released from ergothioneine in a topical, aqueous-containing cosmetic or pharmaceutical composition stored at room temperature prior to application of the composition to skin, said composition having a neutral to acidic pH and comprising greater than 20 μM (w/v) ergothioneine, said method comprising adding to said composition a trimethylamine absorber comprising a weak organic acid in an amount sufficient to bind the trimethylamine so as to prevent development of a fishy odor when the composition is applied to the skin, wherein the trimethylamine absorber is added to the composition before, during or after the storage. |
地址 |
New York NY US |