| 主权项 |
1. A crystalline Form Z1 of O-desmethyl-venlafaxine succinate characterized by:
(a) a solid state 13C nuclear magnetic resonance having the following chemical shifts expressed in parts per million at about 19.9, 24.8, 27.1, 29.1, 29.7, 32.9, 35.4, 37.2, 40.7, 41.5, 43.2, 44.9, 50.0, 52.7, 55.2, 58.6, 61.0, 61.6, 62.1, 73.5, 76.6, 114.3, 126.7, 127.7, 128.4, 131.4, 132.1, 155.2 and 179.0; (b) a water content of about 1.0% to about 2.0% w/w, when analyzed by Karl Fischer method; and (c) a powder XRD pattern having peaks 5.1, 10.3, 12.1 13.3, 14.3, 15.9, 16.7, 17.7, 19.2, 20.0, 20.4, 23.3, 24.5, 25.2, 25.9, 26.7 and 31.4 degrees (±0.2° 2θ). |
