| 摘要 |
The invention relates to 2-(4-Substituted phenylamino) polysubstituted pyridine compounds as inhibitors of non-nucleoside HIV reverse transcriptase, preparation methods and uses thereof. Specifically, the invention relates to compounds of formula I or the pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, R5, R6, R7 and X are as defined in the description. The compounds of formula I of the invention are a type of anti-HIV active compounds having new backbone structure.; |
| 主权项 |
1. A compound of formula Ia: or a pharmaceutically acceptable salt thereof, wherein, R1 and R3 are each independently —NO2, —NH2, halo, —OH, —CN or —N(R)2; R2 is —H; R7 is —CN, —HC═CH—CN, halo, —CH3, —OCH3, —NH2, —CH2—NHR′, —OH, —NO2, —CF3, —C≡CR′, —CH═CHR′, —CH═CHCOR′, —CHO, —C≡CR″, —CH═CHR″, —C≡C—CN, a five-membered heteroaryl containing 1-3 heteroatoms selected from the group consisting of N, O, S, and being optionally substituted on its ring with carbonyl (either aldehyde or ketone group), cyano, α,β-unsaturated cyano, alkenyl, alkynyl, aldehyde group or ketone group; R′ is H or C1-6 hydrocarbyl; R″ is NO2, NH2, or N3; X is —O—, —NH— or —NCOR—; and R is C1-4 hydrocarbyl. |
