Uracyl spirooxetane nucleosides

摘要

Compounds of the formula I:;including any possible stereoisomers thereof, wherein:R4 is a monophosphate, diphosphate or triphosphate ester; or R4 is;R7 is optionally substituted phenyl, optionally substituted naphthyl, or optionally substituted indolyl;R8 and R8′ are hydrogen, C1-C6alkyl, benzyl, or phenyl; or R8 and R8′ form C3-C7cycloalkyl;R9 is C1-C10alkyl, C3-C7cycloalkyl, phenyl or phenyl-C1-C6alkyl, wherein the phenyl moiety in phenyl or phenyl-C1-C6alkyl is optionally substituted;

or a pharmaceutically acceptable salt or solvate thereof;

pharmaceutical formulations and the use of compounds I as HCV inhibitors.

主权项

1. A compound of formula I: including any possible stereoisomers thereof, wherein: R4 is a monophosphate, diphosphate or triphosphate ester or a pharmaceutically acceptable salt thereof.