Dimethyl fasudil for inducing polyploidization of megakaryocytes and for treating blood and bone marrow diseases and disorders

摘要

Disclosed are methods for inducing polyploidization of megakaryocyte cells and for promoting differentiation of megakaryocyte cells into platelet-producing cells. The methods may be utilized for treating blood and bone marrow diseases and disorders in a subject in need thereof and for identifying agents for treating blood and bone marrow diseases and disorders.

主权项

1. A method for treating a patient having a proliferative blood or bone marrow disease or disorder, the method comprising administering to the patient an effective amount of a compound having a formula: wherein the proliferative blood or bone marrow disorder is selected from a group consisting of an Acute Megakaryoblastic Leukemia, a Myeloproliferative Disease, a Myelodysplastic Syndrome, and an Acute Myeloid Leukemia.