| 摘要 |
<p>The present invention relates to radioisotope-labeled and angiogenesis-promoting protein or peptide-loaded polymeric hydrogel, method for preparing the same, and pharmaceutical composition for preventing or treating ischemic disease comprising same as an active ingredient. The polymeric hydrogel according to the present invention directly labels radionuclides on biodegradable polymers and deposits angiogenesis-promoting protein or peptide when forming hydrogel, thereby angiogenesis-promoting protein or peptide is gradually released while staying in disease region in which polymeric hydrogel is accumulated. Therefore, waste of large amount of angiogenesis-promoting protein or peptide can be prevented; particle amount staying in ischemic diseases region can be quantified by checking bio-distribution using a gamma camera; and therapeutic effects can be predicted. In addition, the present invention releases radiation from disease region, thereby being suitably used for treating diseases such as ischemic disease. Therefore, the polymeric hydrogel according to the present invention can expect therapeutic effects by radionuclides and angiogenesis-promoting protein or peptide at the same time, and enhance therapeutic effects of disease region by quantitatively evaluating accumulation of medicines.</p> |
