| 发明名称 |
Process for preparing Bosentan monohydrate and it's intermediates |
| 摘要 |
The present invention relates to a process for preparing Bosentan Monohydrate; in particular, the present invention provides the preparation of the novel 4-tert-butyl-N-[6-(2-hydroxy-ethoxy)-5-(2-methoxy-phenoxy)-2-(2-pyrimidinyl)-pyrimidin-4-yl]-benzenesulfonamide sodium salt as an ethylene glycol solvate (Bosentan sodium salt ethylene glycol solvate), which is a useful intermediate for obtaining Bosentan Monohydrate in a pure form. |
| 申请公布号 |
US8933226(B2) |
申请公布日期 |
2015.01.13 |
| 申请号 |
US201113824620 |
申请日期 |
2011.09.22 |
| 申请人 |
Zach Systems S.p.A. |
发明人 |
Cotarca Livius;Verzini Massimo;Melotto Elisa;Michieletto Ivan;Melloni Alfonso;Maragni Paolo;Volpicelli Raffaella;Andretto Mauro;Colli Corrado |
| 分类号 |
C07D403/04;C07D239/69;C07C31/20 |
主分类号 |
C07D403/04 |
| 代理机构 |
|
代理人 |
Salvadori, P.C. Silvia |
| 主权项 |
1. A crystalline form of Bosentan sodium salt of formula (IV) wherein the crystalline form comprises, as part of its crystalline structure, stoichiometric or non-stoichiometric amounts of ethylene glycol. |
| 地址 |
Bresso (Milano) IT |
