| 主权项 |
1. A compound of formula I:wherein:
the bond represented by - - - is a double bond, R10 is absent, and W is (NR30)+D−; R1 is —NR3aR3b, —C(═NR3cb)—NR3ccR3cd, aryloxy, cyano, or (C1-C6)alkyl that is substituted with one or more —NR3ce−C(═NR3cb)R3ce, —C(═NR3cb)—NR3ccR3cd, —NR3ce—C(═NR3cb)—NR3ccR3cd, and —NR3ce—C(═O)—NR3ccR3cd; at least one of R4, R5, R2′, R3′, and R6′ is aryl or heteroaryl; and the remainder of R4, R5, R2′, R3′, and R6′ is selected from hydrogen, halo, hydroxy, carboxy, cyano, CF3SO3—, (C1-C6)alkyl, (C2-C6)alkenyl, (C2-C6)alkynyl, (C1-C6)alkoxy, cycloalkyl, aryl(C1-C6)alkyl, aryl, heteroaryl, hetero aryl (C1-C6)alkyl, aryl (C1-C6)alkanoyl, and heteroaryl (C1-C6)alkanoyl; wherein each (C1-C6)alkyl, (C2-C6)alkenyl, (C2-C6)alkynyl, (C1-C6)alkoxy, cycloalkyl, and (C1-C6)alkanoyl of R4, R5, R2′, R3′, and R6′ is optionally substituted with one or more groups independently selected from halo, hydroxy, cyano, nitro, (C1-C6)alkoxy, cycloalkyl, oxo, carboxy, aryloxy, sulfo, —S(O)2NR3gR3h, —N(Rj)S(O)2R3k, and —NR3gR3h; and wherein each aryl, and heteroaryl of R4, R5, R2′, R3′, and R6′ is optionally substituted with one or more groups independently selected from (C1-C6)alkyl, halo, hydroxy, cyano, nitro, (C1-C6)alkoxy, cycloalkyl, carboxy, aryloxy, nitro, sulfo, R3aa, —S(O)2NR3gR3h, —N(R3j)S(O)2R3k, and —NR3gR3h; any adjacent R6, R7, R8, R4′ and R5′ taken together can optionally be methylenedioxy and each remaining R6, R7, R8, R4′ and R5′ is independently selected from H, R3bb, and Z—R3x; each Z is independently selected from —O—, —S—, and —N(R3y)—; R30 is absent and D− is absent; or R30 is H or (C1-C6)alkyl and D− is counterion; A is N or C—R4′; R3a is hydrogen, (C1-C6)alkyl, aryl, aryl(C1-C6)alkyl, heteroaryl, or heteroaryl(C1-C6)alkyl; wherein each (C1-C6)alkyl of Ra is optionally substituted with one or more groups selected from halo, hydroxy, cyano, nitro, (C1-C6)alkoxy, cycloalkyl, oxo, carboxy, —NR3daR3db, and aryloxy, and wherein each aryl and heteroaryl of R3a is optionally substituted with one or more groups selected from (C1-C6)alkyl, halo, hydroxy, cyano, nitro, (C1-C6)alkoxy, cycloalkyl, carboxy, and aryloxy; and R3b is hydrogen, (C1-C6)alkyl, aryl, aryl(C1-C6)alkyl, heteroaryl, heteroaryl(C1-C6)alkyl, —C(═NR3cb)—NR3ccR3cd, —C(═NR3cb)— R3ea, —C(═O)—R3m, —C(═O)—OR3n, —C(═O)—SR3p, —C(═O)—NR3qR3r, —C(═S)—R3m, —C(═S)—OR3n, —C(═S)—SR3p, or —C(═S)—NR3qR3r; wherein each (C1-C6)alkyl of R3b is optionally substituted with one or more groups independently selected from halo, hydroxy, cyano, nitro, (C1-C6)alkoxy, cycloalkyl, oxo, carboxy, —NR3daR3db, and aryloxy; and wherein each aryl, and heteroaryl of Rb is optionally substituted with one or more groups independently selected from (C1-C6)alkyl, halo, hydroxy, cyano, nitro, (C1-C6)alkoxy, cycloalkyl, carboxy, and aryloxy; or R3a and R3b taken together with the nitrogen to which they are attached form aziridino, azetidino, morpholino, piperazino, pyrrolidino, pyrrole, indole, or piperidino, which aziridino, azetidino, morpholino, piperazino, pyrrolidino pyrrole, indole, or piperidino can optionally be substituted with one or more (C1-C6)alkyl; R3c is hydrogen, (C1-C6)alkyl, aryl, or heteroaryl; R3d is hydrogen, (C1-C6)alkyl, (C1-C6)alkoxy, (C1-C6)alkylthio, (C1-C6)alkanoyl, or —NR3eR3f; R3e and R3f are each independently selected from H, (C1-C6)alkyl, cycloalkyl, cycloalkyl(C1-C6)alkyl, aryl, heteroaryl, aryl(C1-C6) alkyl and heteroaryl(C1-C6)alkyl; or R3e and R3f together with the nitrogen to which they are attached form a aziridino, azetidino, morpholino, piperazino, pyrrolidino or piperidino; each R3g and R3h is independently selected from H, (C1-C6)alkyl, cycloalkyl, cycloalkyl(C1-C6)alkyl, aryl, heteroaryl, aryl(C1-C6) alkyl and heteroaryl(C1-C6) alkyl; or R3g and R3h together with the nitrogen to which they are attached form a aziridino, azetidino, morpholino, piperazino, pyrrolidino or piperidino; each R3j is independently selected from H, (C1-C6)alkyl, cycloalkyl, cycloalkyl(C1-C6)alkyl, aryl, heteroaryl, aryl(C1-C6) alkyl and heteroaryl(C1-C6)alkyl; each R3k is independently selected from H, (C1-C6)alkyl, cycloalkyl, cycloalkyl(C1-C6)alkyl, aryl, heteroaryl, aryl(C1-C6) alkyl and heteroaryl(C1-C6)alkyl; each R3m is independently selected from H, (C1-C6)alkyl, cycloalkyl, cycloalkyl(C1-C6)alkyl, aryl, heteroaryl, aryl(C1-C6) alkyl and heteroaryl(C1-C6)alkyl; each R3n is independently selected from H, (C1-C6)alkyl, cycloalkyl, cycloalkyl(C1-C6)alkyl, aryl, heteroaryl, aryl(C1-C6) alkyl and heteroaryl(C1-C6)alkyl, wherein each aryl, and heteroaryl is optionally substituted with one or more groups independently selected from (C1-C6)alkyl, halo, hydroxy, cyano, nitro, (C1-C6)alkoxy, cycloalkyl, carboxy, aryloxy, nitro, sulfo, —S(O)2NR3gR3h, —N(R3j)S(O)2R3k, and —NR3gR3h; each R3p is independently selected from H, (C1-C6)alkyl, cycloalkyl, cycloalkyl(C1-C6)alkyl, aryl, heteroaryl, aryl(C1-C6) alkyl and heteroaryl(C1-C6)alkyl, wherein each aryl, and heteroaryl is optionally substituted with one or more groups independently selected from (C1-C6)alkyl, halo, hydroxy, cyano, nitro, (C1-C6)alkoxy, cycloalkyl, carboxy, aryloxy, nitro, sulfo, —S(O)2NR3gR3h, —N(R3j)S(O)2R3k, and —NR3gR3h; each R3q is independently selected from H, (C1-C6)alkyl, cycloalkyl, cycloalkyl(C1-C6)alkyl, aryl, heteroaryl, aryl(C1-C6) alkyl and heteroaryl(C1-C6)alkyl; and each R3r is independently selected from H, (C1-C6)alkyl, cycloalkyl, cycloalkyl(C1-C6)alkyl, aryl, heteroaryl, aryl(C1-C6) alkyl and heteroaryl(C1-C6)alkyl; or R3q and R3r together with the nitrogen to which they are attached form a aziridino, azetidino, morpholino, piperazino, pyrrolidino or piperidino; each R3u and R3v is independently selected from H and (C1-C6)alkyl; each R3x is independently selected from (C1-C6)alkyl, (C1-C6)alkanoyl, and —C(═O)NR3uR3v; each R3y is independently selected from H and (C1-C6)alkyl; each R3aa is independently selected from aryl and heteroaryl, which aryl and heteroaryl is optionally substituted with one or more groups independently selected from (C1-C6)alkyl, halo, hydroxy, cyano, nitro, (C1-C6)alkoxy, cycloalkyl, carboxy, aryloxy, nitro, sulfo, —S(O)2NR3gR3h, —N(R3j)S(O)2R3k, and —NR3gR3h; and each R3bb is independently selected from aryl and heteroaryl, which aryl and heteroaryl is optionally substituted with one or more groups independently selected from (C1-C6)alkyl, halo, hydroxy, cyano, nitro, (C1-C6)alkoxy, cycloalkyl, carboxy, aryloxy, nitro, sulfo, —S(O)2NR3gR3h, —N(R3j)S(O)2R3k, and —NR3gR3h; each R3cb is independently selected from H, (C1-C6)alkyl, (C3-C6)cycloalkyl, (C3-C6)cycloalkyl(C1-C6)alkyl, aryl, heteroaryl, aryl(C1-C6) alkyl and heteroaryl(C1-C6)alkyl; each R3cc and R3cd is independently selected from H, (C1-C6)alkyl, (C3-C6)cycloalkyl, (C3-C6)cycloalkyl(C1-C6)alkyl, aryl, heteroaryl, aryl(C1-C6) alkyl and heteroaryl(C1-C6) alkyl; or R3cc and R3cd together with the nitrogen to which they are attached form a aziridino, azetidino, morpholino, piperazino, pyrrolidino or piperidino; wherein any (C1-C6)alkyl, (C3-C6)cycloalkyl, (C3-C6)cycloalkyl(C1-C6)alkyl, aryl, heteroaryl, aryl(C1-C6) alkyl or heteroaryl(C1-C6)alkyl of R3cc and R3cd is optionally substituted with one or more groups independently selected from hydroxy, carboxy, and NR3cmR3cn; each R3ce is independently selected from H, (C1-C6)alkyl, (C3-C6)cycloalkyl, (C3-C6)cycloalkyl(C1-C6)alkyl, aryl, heteroaryl, aryl(C1-C6) alkyl and heteroaryl(C1-C6)alkyl; each R3cg and R3ch is independently selected from H, (C1-C6)alkyl, (C3-C6)cycloalkyl, (C3-C6)cycloalkyl(C1-C6)alkyl, aryl, heteroaryl, aryl(C1-C6) alkyl and heteroaryl(C1-C6) alkyl; or R3cg and R3ch together with the nitrogen to which they are attached form a aziridino, azetidino, morpholino, piperazino, pyrrolidino or piperidino; wherein any (C1-C6)alkyl, (C3-C6)cycloalkyl, (C3-C6)cycloalkyl(C1-C6)alkyl, aryl, heteroaryl, aryl(C1-C6) alkyl or heteroaryl(C1-C6)alkyl of R3cg and R3ch is optionally substituted with one or more groups independently selected from hydroxy, carboxy, and NR3cmR3cn; each R3cm and R3cn is independently selected from H, (C1-C6)alkyl, (C3-C6)cycloalkyl, (C3-C6)cycloalkyl(C1-C6)alkyl, aryl, heteroaryl, aryl(C1-C6) alkyl and heteroaryl(C1-C6) alkyl; or Rcm and Rcn together with the nitrogen to which they are attached form a aziridino, azetidino, morpholino, piperazino, pyrrolidino or piperidino; each R3da and R3db is independently selected from H, (C1-C6)alkyl, cycloalkyl, cycloalkyl(C1-C6)alkyl, aryl, heteroaryl, aryl(C1-C6) alkyl and heteroaryl(C1-C6) alkyl; or R3da and R3db together with the nitrogen to which they are attached form a aziridino, azetidino, morpholino, piperazino, pyrrolidino or piperidino; and Rea is H, (C1-C6)alkyl, (C1-C6)alkoxy, (C1-C6)alkylthio, or (C1-C6)alkanoyl; or a salt thereof. |
