| 主权项 |
1. A system for focusing ultrasound into a target tissue using a sonication model, the system comprising:
a phased array of ultrasound transducer elements configured to generate an ultrasound focus in the target tissue; an imaging system configured to image the ultrasound focus; and in communication with the imaging system and the phased array of transducer elements, a control facility configured to set relative phases between the transducer elements so as to create a global focus from a plurality of sub-foci, the facility being configured to (i) receive data associated with the sonication model, the data comprising a parameter including at least one of an incidence angle or a predominant type of the target tissue and affecting a reliability of computational phase determinations, (ii) based at least in part on the parameter, group the transducer elements into sub-arrays, at least one of the sub-arrays comprising multiple transducer elements, and compute relative phases of the transducer elements within each sub-array, (iii) drive the transducer elements of the sub-arrays at the respective computed relative phases so as to generate the ultrasound sub-foci, each of which is associated with one of the sub-arrays, and (iv) based at least in part on an image of the ultrasound sub-foci, adjust the relative phases so as to cause constructive interference of the ultrasound foci, thereby generating the global focus. |
