Method for measuring solubility

摘要

A method of determining the solubility of a compound in a selected solvent is provided that does not require determination of, or use of, standards having known concentrations of the compound. In one aspect, the method can include preparation of a mixture where not all of a compound is dissolved in the provided solvent, separating undissolved compound from the solvent, and direct determination of the amount of the compound dissolved in the solvent. Methods adapted for use include those where a multiplicity of compounds or solvents are tested in parallel. Devices adapted for these methods are also provided by the present disclosure.

主权项

1. A method for determining the solubility of a solid compound in a solvent, the method comprising the steps of:
(a) preparing a mixture of a quantity of the solid compound with a volume of the solvent; (b) incubating the mixture of the compound and the solvent to form a solution of the compound, whereby a first portion of the compound dissolves in the solvent to form the solution of the compound, and a second portion of the compound remains undissolved as a solid; (c) removing the undissolved solid compound from the mixture, thereby providing a quantity of the solution of the compound; (d) determining an amount of a constituent in the quantity of the solution of the compound resulting from (c), wherein the determination does not include a comparison of physical properties of one or more solutions containing known concentrations of the compound and physical properties of the solution of the compound; and (e) calculating solubility of the compound in the solvent by determining an amount of the compound dissolved in the quantity of the solution of the compound based on the determination of the amount of the constituent in (d).