Flagellin related polypeptides and uses thereof

摘要

The use of flagellin and flagellin related polypeptides for the protection of mammals from the effects of apoptosis is described.

主权项

1. A composition comprising a Salmonella flagellin polypeptide of the following formula:
amino terminal domain-linker-carboxyl terminal domain,wherein
(a) the amino terminal domain is an amino acid sequence that is at least 95% identical to amino acids 1-174 of SEQ ID NO: 1; (b) the carboxyl terminal domain is an amino acid sequence of amino acids 402-505 of SEQ ID NO: 1 or 402-450 of SEQ ID NO: 1 and (c) the linker is the amino acid sequence of SEQ ID NO: 3 or SEQ ID NO: 4; andwherein the flagellin polypeptide is capable of inducing NF-kB activity and has an immunogenicity that is less than 5% compared to the immunogenicity of SEQ ID NO: 1.