| 发明名称 |
BENZAMINE DERIVATIVES FOR INHIBITING THE ACTIVITY OF ABL1, ABL2 AND BCR-ABL1 |
| 摘要 |
<p>The present invention relates to compounds of formula (I): in which Y, Y1, R1, R2, R3 and R4 are defined in the Summary of the Invention; capable of inhibiting the activity of BCR-ABL1 and mutants thereof. The invention further provides a process for the preparation of compounds of the invention, pharmaceutical preparations comprising such compounds and methods of using such compounds in the treatment of cancers.</p> |
| 申请公布号 |
PH12014502531(A1) |
申请公布日期 |
2015.01.12 |
| 申请号 |
PH12014502531 |
申请日期 |
2014.11.13 |
| 申请人 |
NOVARTIS AG |
发明人 |
DODD, STEPHANIE KAY;FURET, PASCAL;GROTZFELD, ROBERT MARTIN;JAHNKE, WOLFGANG;JONES, DARRYL BRYNLEY;MANLEY, PAUL;MARZINZIK, ANDREAS;PELLE, XAVIER FRANCOIS ANDRE;SALEM, BAHAA;SCHOEPFER, JOSEPH |
| 分类号 |
A61K31/4439;A61P35/00;C07D213/82;C07D401/04;C07D401/14;C07D403/10 |
主分类号 |
A61K31/4439 |
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