METHOD FOR BIOENCAPSULATION

摘要

FIELD: medicine, pharmaceutics.SUBSTANCE: invention refers to bioencapsulation, particularly to a method for cephalosporin bioencapsulation, wherein a microcapsule coating is human leucocyte ?- or ?-interferon. According to the method, power cephalosporin 0.060 g or 0.075 g respectively and E472c preparation 0.05 g as a surfactant are added to 1% aqueous human leucocyte ?- or ?-interferon 2 g or 2.5 g; the prepared mixture is stirred until the ingredients of the reaction mixture are dissolved completely. Forming a transparent solution is followed by slow drop-by-drop addition of methyl carbinol 1 ml as a first precipitating agent and isopropanol 5 ml as a second precipitating agent; then acetone is added, and the mixture is dried. The method is implemented at 25°C with no special equipment applied.EFFECT: simplifying and accelerating the process of microcapsules in interferon and higher weight yield.4 ex