| 摘要 |
FIELD: medicine, pharmaceutics.SUBSTANCE: invention refers to pyrazolopyridine derivatives of formula (I), a based pharmaceutical composition, and using them for treating and/or preventing disorders or conditions related to nictonamide adenine dinucleotide phosphatoxidase (NADPH-oxidase), as well as to a method for preparing them and an intermediate of formula (VIII). In general formula (I), Gis specified in H; and optionally substituted heteroaryl-C-C-alkyl; Gis specified in H; optionally substituted C-C-alkyl; optionally substituted C-C-alkenyl; optionally substituted C-C-alkinyl; optionally substituted aryl; optionally substituted C-C-alkylaryl; optionally substituted aryl-C-C-alkyl; optionally substituted heteroaryl; optionally substituted C-C-alkylheteroaryl; optionally substituted heteroaryl-C-C-alkyl; optionally substituted C-C-alkenylaryl; optionally substituted aryl-C-C-alkenyl; optionally substituted C-C-alkenylheteroaryl; optionally substituted heteroaryl-C-C-alkenyl; optionally substituted C-C-cycloalkyl; optionally substituted C-C-heterocycloalkyl; optionally substituted C-C-alkyl-C-C-cycloalkyl; optionally substituted C-C-cycloalkyl-C-C-alkyl; optionally substituted C-C-alkyl-C-C-heterocycloalkyl and optionally substituted C-C-heterocycloalkyl-C-C-alkyl; Gis specified in H; optionally substituted amino; optionally substituted aminoalkyl; optionally substituted aminocarbonyl; optionally substituted alkoxy, optionally substituted alkoxy-C-C-alkyl; optionally substituted carbonyl; optionally substituted C-C-alkyl; optionally substituted C-C-alkenyl; optionally substituted C-C-alkinyl; optionally substituted aryl; optionally substituted aryl-C-C-alkyl; optionally substituted C-C-alkylaryl: optionally substituted heteroaryl; optionally substituted C-C-alkylheteroaryl; optionally substituted heteroaryl-C-C-alkyl; optionally substituted C-C-alkenylaryl; optionally substituted aryl-C-C-alkenyl; optionally substituted C-C-alkenylheteroaryl; optionally substituted heteroaryl-C-C-alkenyl; optionally substituted C-C-cycloalkyl; optionally substituted C-C-heterocycloalkyl; optionally substituted C-C-alkyl-C-C-cycloalkyl; optionally substituted C-C-cycloalkyl-C-C-alkyl; optionally substituted C-C-alkyl-C-C-hterocycloalkyl and optionally substituted C-C-heterocycloalkyl-C-C-alkyl; Gis specified in -NR-C(O)-Rand -(CHR)-(CH)-R, Grepresents H.EFFECT: preparing the pharmaceutical composition for treating and/or preventing the disorders and conditions related to nictonamide adenine dinucleotide phosphatoxidase.16 cl, 3 tbl, 87 ex |
