| 发明名称 |
Treatment and Prevention of Gardnerella Vaginalis Infections |
| 摘要 |
The present invention is drawn to the nucleic and amino acid sequences encoding vaginolysin (VLY) toxin from Gardnerella vaginalis, and biologically active fragments and variants thereof. The invention is also directed to anti-VLY antibodies and to their use therapeutically and in a new ELISA assay of VLY toxin. Other embodiments of the invention are directed to VLY toxoids and to vaccines that use the new VLY toxoids as immunogens. |
| 申请公布号 |
US2015010579(A1) |
申请公布日期 |
2015.01.08 |
| 申请号 |
US201414332374 |
申请日期 |
2014.07.15 |
| 申请人 |
Ratner Adam J. |
发明人 |
Ratner Adam J. |
| 分类号 |
C07K14/195;A61K39/02;A61K39/395;C07K16/28;G01N33/569;C07K16/12 |
主分类号 |
C07K14/195 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method for permeabilizing a cell membrane, comprising contacting the cell with a composition comprising isolated and purified G. vaginalis VLY protein, or a biologically active fragment or variant thereof. |
| 地址 |
New York NY US |
