METHOD FOR PREPARATION OF (2-HYDROXY-3-OXO-CYCLOPENT-1-ENYL)-ACETIC ACID ESTERS

摘要

PROBLEM TO BE SOLVED: To provide a method for preparation of (2-hydroxy-3-oxo-cyclopent-1-enyl)-acetic acid esters represented by the formula I, which are precursors of homocitric acid derivatives and salts thereof. ! SOLUTION: A method for preparation of (2-hydroxy-3-oxo-cyclopent-1-enyl)-acetic acid esters represented by the formula I comprises a coupling reaction of 3-halogeno-2-hydroxy-cyclopent-2-en-1-ones represented by the formula II with zinc derivatives of bromoacetic acid esters in the presence of palladium catalysts. ! COPYRIGHT: (C)2015,JPO&INPIT