PYRIDAZINE DERIVATIVES AND USE THEREOF AS MEDICAMENTS FOR TREATING MICRORNA VIRAL INFECTION

摘要

Disclosed are pyridazine derivatives represented by Formula I or pharmaceutically acceptable salts or hydrates thereof, pharmaceutical compositions comprising the compounds, methods of treating and/or preventing diseases or disorders associated with viral infections in patients using the compounds, and the use of the compounds in preparing the medicaments for treating and/or preventing diseases or disorders associated with viral infections. The compounds represented by Formula I have antiviral activity, especially anti-microRNA viral activity. Symbols in the compounds represented are described in the specification.;

主权项

1. A method for treating or preventing a disease or disorder associated with an infection caused by a picornavirus in a subject in need thereof comprising administrating a compound having Formula Ia or a pharmaceutically acceptable salt thereof to the subject, wherein R1 is chlorine; n is 3 or 4; and R4 is a straight or branched C1-C6 alkyl.