THERAPEUTIC AGENT DELIVERY SYSTEM AND METHOD

摘要

A therapeutic agent delivery system includes a therapeutic agent delivery platform and a therapeutic guest agent. The therapeutic agent delivery platform is capable of being implanted in a tissue being treated. The platform includes a substrate and at least one host molecule coupled to the substrate. The therapeutic guest agent is capable of reversibly coupling with the host molecule when administered to the tissue being treated. The reversible coupling is defined by the binding affinity between the host molecule and the therapeutic guest agent. The therapeutic guest agent is delivered at a rate determined by the affinity release rate between the host molecule and the therapeutic guest agent. The degradation rate of the therapeutic guest agent may be slower than the affinity release rate between the host molecule and the therapeutic guest agent.

主权项

1. A method for delivering a therapeutic guest agent to a subject, comprising:
placing a therapeutic guest agent delivery platform at a desired location in the subject, the delivery platform comprising a polymer substrate, at least one cyclodextrin host molecule coupled to the substrate, and therapeutic guest agent that is reversibly coupled to the host molecule; allowing the therapeutic guest agent to be released from the host molecule at the desired location; and reloading the therapeutic guest agent delivery platform by contacting the therapeutic agent delivery platform with additional therapeutic guest agent.