| 摘要 |
The present invention provides a compound which enhances the production of erythropoietin. The present invention provides, for example, a compound represented by the formula (1) wherein R1: -Q1, -Q1-X-Q2, or -Q1-X-Q2-Y-Q3: a monocyclic or bicyclic aromatic heterocyclic group; Q2, Q3: an aromatic hydrocarbon ring group or a monocyclic aromatic heterocyclic group; X: —CONH—, —CONHCH2—, —CH2OCH2—, —NHCH2CH2—, or the like; Y: a single bond, —O—, —(CH2)n—, or —O—(CH2)n—; m, n: an integer from 1 to 3; R2: H or an alkyl group; and R3: H, an alkoxycarbonyl group, a carboxy group, an aromatic hydrocarbon ring group, or a monocyclic aromatic heterocyclic group. |
| 主权项 |
1. A compound represented by the following general formula (1):or a pharmacologically acceptable salt thereof,wherein
R1 represents a group represented by -Q1, -Q2-X-Q2, or -Q1-X-Q2-Y-Q3; Q1 represents a monocyclic or bicyclic aromatic heterocyclic group which may have 1 or 2 substituents independently selected from substituent group α; substituent group α represents the group consisting of a halogen atom, a C1-C6 alkyl group, a halo C1-C6 alkyl group, a C1-C6 alkoxy group, a C3-C7 cycloalkyl group, and a 4- to 7-membered heterocycloalkyl group; Q2 represents an aromatic hydrocarbon ring group which may have 1 or 2 substituents independently selected from substituent group β, or a monocyclic aromatic heterocyclic group which may have 1 or 2 substituents independently selected from substituent group β; substituent group β represents the group consisting of a halogen atom, a C1-C6 alkyl group, a halo C1-C6 alkyl group, a C1-C6 alkoxy group, a C3-C7 cycloalkyl group, and a cyano group; Q3 represents an aromatic hydrocarbon ring group which may have 1 or 2 substituents independently selected from substituent group γ, or a monocyclic aromatic heterocyclic group which may have 1 or 2 substituents independently selected from substituent group γ; substituent group γ represents the group consisting of a halogen atom, a C1-C6 alkyl group, a halo C1-C6 alkyl group, a C1-C6 alkoxy group, a C3-C7 cycloalkyl group, and a cyano group; X represents a single bond, -(CH2)n—, —CH═CH—, —CONH—, —NHCO—, —CONHCH2—, —NHCOCH2—, —CH2NHCO—, —CH2CONH—, —SO2NH—, —CH2OCH2—, or —NHCH2CH2—; Y represents a single bond, —O—, —(CH2)n—, or —O—(CH2)n—; m and n each independently represents an integer from 1 to 3; R2 represents a hydrogen atom or a C1-C6 alkyl group; and R3 represents a hydrogen atom, a C1-C6 alkoxycarbonyl group, a carboxy group, an aromatic hydrocarbon ring group, or a monocyclic aromatic heterocyclic group. |
