Various aspects and embodiments of the present disclosure are directed to methods and compositions for functionalizing endogenous bacteria in vivo. The methods include delivering to endogenous bacterial cells a recombinant bacteriophage or phagemid that is engineered to contain at least one genetic circuit.
申请公布号
WO2015002939(A1)
申请公布日期
2015.01.08
申请号
WO2014US45034
申请日期
2014.07.01
申请人
MASSACHUSETTS INSTITUTE OF TECHNOLOGY;TRUSTEES OF BOSTON UNIVERSITY