发明名称 |
SOFT PROTEASE INHIBITORS AND PRO-SOFT FORMS THEREOF |
摘要 |
The invention provides compounds and methods for inhibiting proteases. One aspect of the invention features pro-soft inhibitors which react with an activating protease to release an active inhibitor moiety in proximity to a target protease. In certain instances, compounds inhibit proteasomes and/or post-proline cleaving enzymes (PPCE), such as dipeptidyl peptidase IV. The compounds of the invention provide a better therapeutic index, owing in part to reduced toxicity and/or improved specificity for the targeted protease. |
申请公布号 |
KR20150003157(A) |
申请公布日期 |
2015.01.08 |
申请号 |
KR20147024336 |
申请日期 |
2006.12.15 |
申请人 |
TRUSTEES OF TUFTS COLLEGE |
发明人 |
LAI HUNG SEN;WU WENGEN;BACHOVCHIN WILLIAM W. |
分类号 |
C07D403/12;A61K31/69;C07D207/04 |
主分类号 |
C07D403/12 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|