TUBULAR TISSUE-ENGINEERED CONSTRUCTS

摘要

The present invention provides constructs including a tubular biodegradable polyglycolic acid scaffold, wherein the scaffold may be coated with extracellular matrix proteins and substantially acellular. The constructs can be utilized as an arteriovenous graft, a coronary graft, a peripheral artery bypass conduit, or a urinary conduit. The present invention also provides methods of producing such constructs.

主权项

1. A tubular construct comprising extracellular matrix proteins and polyglycolic acid having thickness greater than about 200 μm at the thinnest portion of the construct and having an internal diameter of ≧3 mm, wherein the construct is intimal hyperplasia and calcification resistant, wherein the polyglycolic acid comprises less than 33% of the cross-sectional area of said construct and wherein the construct is substantially acellular comprising less than 5% intact cells.