METHODS OF ADMINISTERING ANTI-TNFα ANTIBODIES

摘要

PROBLEM TO BE SOLVED: To provide novel methods of treating disorders in which TNFα activity is detrimental.SOLUTION: Human antibodies, preferably recombinant human antibodies, that specifically bind to human tumor necrosis factor α (hTNFα) are subcutaneously administered biweekly. The antibodies may be administered with methotrexate. The antibodies have high affinity for hTNFα (e.g., K=10M or less), a slow off rate for hTNFα dissociation (e.g., K=10secor less) and neutralize hTNFα activity in vitro and in vivo. The antibodies are full-length antibodies or antigen-binding portions thereof.