SYSTEMS AND METHODS FOR CHARACTERIZING LUPUS ERYTHEMATOSUS

摘要

The present invention provides systems and methods for characterizing biological markers in the urine of systemic lupus erythematosus (SLE) subjects. In particular, the present invention relates to the detection of cytokines and chemokines in urine of SLE subjects for determining nephritic disease states and kidney damage in SLE subjects and the efficacy of agents and interventions used to treat lupus nephritis.

主权项

1. A method of detecting and treating a disorder of the kidney associated with systemic lupus erythematosus, comprising:
a) obtaining a urine sample from a subject, having systemic lupus erythematosus; b) having said urine sample tested to quantify the amount of osteoprotegerin in said urine sample; and c) initiating or increasing therapy for said disorder of the kidney associated with systemic lupus erythematosus if said amount of osteoprotegerin is above a threshold level.