发明名称 |
Modifications for Antisense Compounds |
摘要 |
The invention pertains to modifications for antisense oligonucleotides, wherein the modifications are used to improve stability and provide protection from nuclease degradation. The modifications could also be incorporated into double-stranded nucleic acids, such as synthetic siRNAs and miRNAs. |
申请公布号 |
US2015011744(A1) |
申请公布日期 |
2015.01.08 |
申请号 |
US201414281646 |
申请日期 |
2014.09.26 |
申请人 |
Integrated DNA Technologies, Inc. |
发明人 |
Behlke Mark Aaron;Owczarzy Richard;You Yong;Walder Joseph Alan;Lennox Kim |
分类号 |
C12N15/113 |
主分类号 |
C12N15/113 |
代理机构 |
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代理人 |
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主权项 |
1. An antisense oligonucleotide comprising at least one modification that is incorporated between two bases of the antisense oligonucleotide, wherein the modification increases binding affinity and nuclease resistance of the antisense oligonucleotide. |
地址 |
Coralville IA US |