NON ANTI-COAGULATIVE GLYCOSAMINOGLYCANS COMPRISING REPEATING DISACCHARIDE UNIT AND THEIR MEDICAL USE

摘要

The present invention relates to a chemically modified glycosaminoglycan with an antifactor II activity of less than 10 IU/mg, an antifactor Xa activity of less than 10 IU/mg and an average molecular weight (Mw, weight average) from about 4.6 to 6.9 kDa. Also disclosed is a method of preparing the modified glycosaminoglycan and its medical uses.

主权项

1. A chemically modified glycosaminoglycan selected from the group consisting of heparin and heparan sulfate, with an antifactor IIa activity of less than 10 IU/mg, an antifactor Xa activity of less than 10 IU/mg and an average molecular weight (Mw) from about 4.6 to about 6.9 kDa, wherein:
the polysaccharide chains have from 2 to 20 (n in Formula I below) disaccharide units corresponding to molecular weights between 1.2 and 12 kDa; the polysaccharide chains are essentially free of chemically intact saccharide sequences mediating the anticoagulant effect; the predominantly occurring disaccharide is (Formula I) n is an integer from 2 to 20; and the non-reducing end unsaturated glucosamines are present as signals in the interval of 5.0 to 6.5 ppm in a 1H-NMR spectrum with an intensity (% ratio) of less than 4% in relation to the signal at 5.42 ppm from native heparin.