METHOD FOR SCREENING AN AGENT BEING USEFUL FOR THE TREATMENT OF DRY EYE AND /OR CORNEAL AND CONJUNCTIVAL LESION AND A PHARMACEUTICAL COMPOSITION OBTAINED BY THE METHOD

摘要

The present invention provides a method for screening an agent being useful for the treatment of dry eye and/or corneal and conjunctival lesion of dry eye severity level 3 or more according to the report of the International Dry Eye WorkShop (DEWS Report) (2007) and a pharmaceutical composition comprising the agent. The present invention further provides a method for the treatment of dry eye and/or corneal and conjunctival lesion of dry eye severity level 3 or more according to DEWS Report (2007) using the agent.

主权项

1. A method for the treatment of dry eye and/or corneal and conjunctival lesion, which comprises administering an effective amount of an agent to a patient having dry eye and/or corneal and conjunctival lesion of dry eye severity level 3 or more according to DEWS Report (2007), wherein the agent is obtained by a method for screening an agent being useful for the treatment of dry eye and/or corneal and conjunctival lesion of dry eye severity level 3 or more according to the report of the International Dry Eye WorkShop (DEWS Report) (2007), wherein the method for screening an agent comprises:
preparing a model rabbit of corneal and conjunctival lesion having corneal and conjunctival epithelial abrasion by instilling n-heptanol solution to an eye of a rabbit; and administering a test agent to the eye of the model rabbit and determining an effect of restoring corneal tissue of the test agent.