FILLER COMPRISING BEADS

摘要

The present invention pertains to a filler comprising beads wherein the beads comprise a polyanionic biopolymer and divalent cations and wherein the polyanionic biopolymer is not alginate. Further, the present invention pertains to a process for manufacturing the claimed filler, and to an injection device comprising the filler.

主权项

1. A method for augmenting tissue, repairing tissue, strengthening tissue, or for filling a cavity in a mammal, comprising administering by injection to the mammal an effective amount of a filler comprising beads, wherein the beads comprise pectin and at least one divalent cation wherein:
a. the pectin has a degree of amidation of from about 0% to about 30%; b. the pectin has a degree of esterification of from about 0% to about 60%; c. the pectin has a molecular weight distribution from about 50 to about 5000 kDa; and/or d. the at least one divalent cation is selected from the group consisting of calcium, barium, zinc and copper, and mixtures thereof, andwherein the beads exhibit a mass median diameter of less than or equal to 1500 μm as determined by laser diffraction analysis.