BIOMARKERS OF CANCER

摘要

The present invention relates to identification of a transcriptional signature of RalA and RalB GTPase proteins that is present in human cancer cells, and methods of treating the cancer, methods of diagnosis of the cancer, methods of determining predisposition to the cancer, methods of monitoring progression/regression of the cancer, methods of assessing efficacy of compositions for treating the cancer, methods of screening compositions for activity in modulating biomarker of the cancer, as well as other methods and assay systems based on the signature.

主权项

1. A method for monitoring the progression of cancer in a subject, the method comprising:
a) measuring the expression level of a plurality of markers in a first biological sample obtained from the subject, wherein the plurality of markers comprise a plurality of markers selected from the group consisting of:
i) a marker gene having at least 95% sequence identity with a gene selected from the Table 5, or homologs or variants thereof;ii) polypeptides encoded by the marker genes of i)iii) fragments of polypeptides of ii); andiv) a polynucleotide which is fully complementary to at least a portion of a marker gene of i); b) measuring the expression level of the plurality of markers in a second biological sample obtained from the subject; and c) comparing the expression level of the markers measured in the first sample with the level of the markers measured in the second sample.