| 发明名称 |
COMBINATION THERAPY OF AN AFUCOSYLATED CD20 ANTIBODY WITH A CD22 ANTIBODY-DRUG CONJUGATE |
| 摘要 |
The present invention is directed to the combination therapy of an afucosylated anti-CD20 antibody with a CD22 antibody-drug conjugate for the treatment of cancer, especially to the combination therapy of CD20 expressing cancers with an afucosylated humanized B-Ly1 antibody and a CD22 antibody-drug conjugate. |
| 申请公布号 |
US2015010540(A1) |
申请公布日期 |
2015.01.08 |
| 申请号 |
US201414265857 |
申请日期 |
2014.04.30 |
| 申请人 |
HOFFMANN-LA ROCHE INC. ;GENENTECH, INC. |
发明人 |
Klein Christian;Lang Sabine;Umana Pablo;Polson Andrew |
| 分类号 |
C07K16/28;A61K45/06;A61K47/48;A61K39/395 |
主分类号 |
C07K16/28 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1: An afucosylated anti-CD20 antibody with an amount of fucose of 60% or less of the total amount of oligosaccharides (sugars) at Asn297, for the treatment of cancer in combination with a CD22 antibody-drug conjugate. |
| 地址 |
Little Falls NJ US |
