PATIENT SERUM/PLASMA SAMPLE RESISTIVITY FOR ELECTROLYTE RESULT VERIFICATION

摘要

Verification of patient sample electrolyte results using a separate quantitative measurement of sample resistivity. Sample resistivity may be used to measure small differences in resistivity of one sample to the next, and in comparison to a standard solution, in order to verify the results of sample electrolyte measurements being measured at the same time by, for example, individual ion selective electrodes (ISE) in a clinical analyzer. Providing a separate or secondary quantitative means for verification of the measured results of sample electrolytes using sample resistivity solves the problem of electrolyte result variability in sample electrolyte measurements. The process may compare a measured sample resistivity to an expected resistivity value as a verification of the accuracy of individual electrolyte results. Suspect samples—e.g., where the electrolyte resistivity results do not fit the expected resistivity—may be flagged. This separate verification step provides added confidence in the measured electrolyte results and can identify when problems occur or interferences are present in real time.

主权项

1. A sample resistivity measurement system for sample electrolyte result verification comprising:
a sample cartridge for performing sample electrolyte measurements, said sample cartridge comprising:
one or more ion selective electrodes;a common reference electrode to provide a constant reference potential;a circuit connecting each of said one or more ion selective electrodes with said reference electrode;an electrometer connected to said circuit to measure a potential of said one or more ion selective electrodes against said reference electrode;wherein concentrations of desired ions are calculated from an electrode voltage difference between a sample having unknown ion concentration and unknown resistivity and a standard solution having known ion concentration and known resistivity to obtain a measured sample electrolyte result, wherein said sample and said standard solution are run alternately in series through said sample cartridge; a measured sample resistivity of said sample; a measured sample resistivity of said standard solution used to establish a response slope for said one or more ion-selective electrodes and to provide a reference point against which said sample is compared; a resistivity ratio calculated from said measured sample resistivity of said sample and said measured sample resistivity of said standard solution; historical data comprising one or more of: measured sample electrolyte concentrations, and measured sample resistivities; an expected sample resistivity response developed from said historical data; and a tolerance about said expected sample resistivity response, wherein said measured sample electrolyte result is verified to be an acceptable result if said measured sample resistivity falls within said tolerance about said expected sample resistivity response.