Monoclonal antibodies that bind and inhibit biological activities of human Notch1 are disclosed. The antibodies can be used to treat cell proliferative diseases and disorders, including certain forms of cancer, associated with activation or over-expression of Notch1.
申请公布号
WO2014172653(A3)
申请公布日期
2015.01.08
申请号
WO2014US34673
申请日期
2014.04.18
申请人
AVEO PHARMACEUTICALS, INC.
发明人
OKAMURA, HEIDI;BELL, ALISA, C.;CHEN, TING;JIANG, FENG;LIN, JIE;O'HAGAN, RONAN;POLING, LAURA;PROIA, THERESA;WINSTON, WILLIAM, M, JR.
