| 摘要 |
PROBLEM TO BE SOLVED: To provide a method for crystallizing nafamostat mesilate, which suppresses nafamostat mesilate from becoming a gel-like lump in a solution and obtains high-purity nafamostat mesilate. SOLUTION: The method for crystallizing nafamostat mesilate includes having a process for adding acetone to nafamostat mesilate dissolved in a mixed liquid of an aqueous solvent and water in the volume ratio of the aqueous solvent: water of 9:1-1:9 in a temperature range of -10 to 45°C. The mixed liquid of the aqueous solvent and water is preferably a mixed liquid having a volume ratio of the aqueous solvent:water of 4:6-7:3. COPYRIGHT: (C)2012,JPO&INPIT |
